Study of COVID-19

-

 Application of Separation Techniques in Novel Corona virus (COVID-19) Research

Separation Techniques like liquid chromatography is used for purification of many different biomolecules. After a chromatographic separation, the fractions containing the target molecules are identified with specific detection. These fractions with the desired molecules are collected and used for next process steps. RNA purification with the help of chromatography is done at higher pressure and temperatures. Fast Protein Liquid Chromatography (FPLC) is a standard method in research with proteins for many years. With the help of FPLC the structure and activity of the isolated proteins can be investigated. The therapeutic potential of mRNA is extensively discussed in times of search for vaccines in the research of COVID-19. 

The idea is to provide the human body with mRNA, encoding therapeutic proteins, which the immune system uses to fight the virus. RNA can be produced and applied much easier compared to the full-length therapeutic proteins it is encoding for. In order to generate pure mRNA to administer, it was found that purification by chromatographic means is highly important. Research on virus specific proteins focusses for example on structural biology in order to analyze the structure of biomolecules and how alterations in their structures affect their function. Understanding the protein function on the molecular level gives valuable information for drug and vaccine development. The Journal of Chromatography and Separation Techniques aims to publish such novel work on chromatography/separation techniques which aids in COVID-19 Research.

Comments

Post a Comment

Medical Health Sciences

Popular posts from this blog

STUDY OF UGIT (P-14)

-
Image
  14- Obesity An estimated 60 percent of Americans aged 20 years and older are considered overweight and one-quarter are considered obese. Being overweight means that you have an excess amount of body weight, including muscle, bone, fat and water. Being obese means that you have an excess amount of body fat. Obesity significantly increases your risk of developing life-threatening conditions, such as heart disease, stroke, high blood pressure, type 2 diabetes and some forms of cancer. Each year, approximately 280,000 adults die from an obesity-related condition in the United States. Additionally, studies have shown that people who are overweight often suffer from societal discrimination, which may lead to depression, self-esteem and body issue problems. Causes of Obesity Obesity is a complex and chronic disease with many causes. It is not simply a result of overeating. Research has shown that genetics can play a significant role in determining a person's body weight, particula...
Read more

Basic Components of the Immune System

-
Image
INTRODUCTION      It is generally believed that the immune system evolved as the host’s defense against infectious agents, and it is well known that patients with deficiencies in the immune system generally succumb to these infectious diseases. However, as we shall see, it may well play a larger role in the elimination of other foreign substances, including tumor antigens or cells and antibodies that attack self. An immune response may be conveniently divided into two parts:  1) a specific response to a given antigen and  2) a more nonspecific augmentation to that response.       An important feature of the specific response is that there is a quicker response to the antigen during a second exposure to that antigen. It is the memory of the initial response that provides the booster effect. For convenience, the specific immune response may be divided into two parts:  1) the humoral response and  2) ...
Read more

Pulmonary Hypertension

-
Image
WHO Classification of Pulmonary Hypertension Group I. Pulmonary Arterial Hypertension Idiopathic primary Familial and related Disorders collagen vascular disease, congenital systemic to pulmonary shunts, portal hypertension, HIV, drugs and toxins, thyroid disorders, glycogen storage disease, Gaucher’s disease, hereditary hemorrhagic telangiectasia, hemoglobinopa thies, myeloproliferative disorders, splenectomy Associated with Significant Venous or Capillary Involvement pulmonary venoocclusive disease, pulmonary capillary hemangiomatosis Persistent Pulmonary Hypertension of Newborn Group II. Pulmonary venous Hypertension left sided atrial or ventricular heart disease, left sided valvular heart disease Group III. Pulmonary Hypertension associated with Hypoxemia COPD, interstitial lung disease, sleep disordered breathing, alveolar hypoventilation disorders, chronic exposure to high altitude, developmental abnormalities Group IV. Pulmonary Hypertension due to chronic Thromb...
Read more